Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid CAS Number: 1640282-31-0

CAS Number: 1640282-31-0

CGK733 (10 μM) results in 1

10 mM SB431542

Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK

Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid CAS Number: 1640282-31-0Rapamycin, CAS No. 53123 88 9, is a potent and selective mTOR inhibitor. Rapamycin, in complex with the cytosolic protein FK binding protein 12 (FKBP12), inhibits mTOR Complex 1 (mTORC1) by binding to the FRB domain of mTor. Given the central roles mTor plays, Rapamycin showed diverse activities, including anti proliferative effects in cancer cells, immunosuppressive effect, lifespan extension in mice, improved cognition in the mouse model of autism