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(Rac)-Calpain Inhibitor XII inib bromide EMPA inhibits orexin-A-or orexin-B-evoked [Ca2+]i

SKU: 25841508155

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Description

EMPA inhibits orexin-A-or orexin-B-evoked [Ca2+]i response with IC50s of 8

6R)-2-{3-hydroxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenoxy}-6-(hydroxymethyl)oxane-3

50 uM/20 uM compound concentration's inhibitory percentage are 75%/67% for chitinase/N- acetyl-hexosaminidase respectively

ClH/c1-3-26(35)15-6-19-23-13(9-31(19)24(33)14(15)10-36-25(26)34)22-17(29-20(32)8-28)5-4-12-11(2)16(27)7-18(30-23)21(12)22

(Rac)-Calpain Inhibitor XII inib bromide EMPA inhibits orexin-A-or orexin-B-evoked [Ca2+]i(Rac) Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I ( calpain, Ki=19 nM). (Rac) Calpain Inhibitor XII has lower affinities for calpain II (m calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac) Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury. Product information CAS Number: 181769 57 3

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