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6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S
while in vivo this compound showed oral and intravenous activity in NK-3 receptor-driven models (senktide-induced behavioral responses in mice and senktide-induced miosis in rabbits)
BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25
and constipation
Regorafenib Hydrochloride - CAS# 835621-07-3 Catalog No.:M10444-10 6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1SRegorafenib (Stivarga, BAY 73 4506) Hydrochloride is a multi target inhibitor for VEGFR1, Murine VEGFR2 3, PDGFR, Kit (c Kit), RET (c RET) and Raf 1 with IC50 of 13 nM, 4. 2 nM 46 nM, 22 nM, 7 nM, 1. 5 nM and 2. 5 nM, respectively. Product information CAS Number: 835621 07 3 Molecular Weight: 519. 28 Formula: C21H16Cl2F4N4O3 Synonym: BAY73 4506 hydrochloride Chemical Name: 4 [4 ({[4 chloro 3 (trifluoromethyl)phenyl]carbamoyl}amino) 3 fluorophenoxy] N